Tim Angeli-Gordon

Affiliations

Tauiwi

Relevant Qualifications

2023: Certificate Level 4, Te Ara Reo Māori He Pī ka Rere, Te Wānanga o Aotearoa.

2014: Doctor of Philosophy in Bioengineering, Waipapa Taumata Rau University of Auckland.

2009: Master of Science in Engineering, Biomedical Engineering, University of Michigan, USA.

2008: Bachelor of Science in Engineering, Biomedical Engineering (Magna Cum Laude), University of Michigan, USA

Expertise

Tim’s research career focuses on measuring and monitoring the underlying electrical control of the stomach and intestine, with a specific focus on developing new devices and techniques that can be used to diagnose and treat gastrointestinal disorders. In addition to his role at Te Wānanga o Aotearoa, he also works with the Auckland Bioengineering Institute (ABI) and Department of Surgery at Waiapapa Taumata Rau, University of Auckland, for his research. He is the director of the Laboratory for TrAnslational Research in Gastroenterology and Emerging Technologies (TARGET Lab), and his research is supported, or has previously been supported, by:

-       a Rutherford Discovery Fellowship from the Royal Society Te Apārangi,

-       an Edith C Coan Fellowship from the Auckland Medical Research Foundation,

-       the Marsden Fund,

-       the Health Research Council of New Zealand,

-       the National Science Challenge on High-Value Nutrition from the Ministry of Business, Innovation, and Employment (MBIE),

-       Te Tītoki Mataora MedTech Research Translator,

-       the New Zealand Society of Gastroenterology.

In his role as the Senior Rangahau & Innovation Manager at Te Manawahoukura, he now uses his research experience to āwhina the various kairangahau and kaimahi within Te Wānanga o Aotearoa to map out their rangahau journey and realise their rangahau aspirations. Tim is passionate about supporting kairangahau, mātauranga Māori, and te reo Māori, which is a key aspect that attracted him to Te Manawahoukura. He has two daughters, and he envisions an opportunity for them to contribute to a flourishing rangahau space in Aotearoa when they are grown.

Prior to joining Te Manawahoukura, Tim worked in the Gastrointestinal Research Group at the ABI from December 2009 when he began his PhD there. His PhD research investigated the underlying electrophysiological control of the small intestine using high-resolution electrical mapping, and he graduated with his PhD in May 2014.

Prior to joining the ABI in Aotearoa, Tim attended the University of Michigan, USA, where he graduated with his Bachelor of Science in Engineering (2008) and Master of Science in Engineering (2009), both in Biomedical Engineering. He investigated new methods of drug delivery based on the human body's natural immune response for his Master's research, and also worked at a biotechnology company where he was involved in the research and development of a bioartificial kidney.

Tim enjoys spending time with his wife and two daughters, is a fledgling squash player, and is an avid kaihī ika and kaiaru. The ngahere and moana are where he feels mauritau.

Key Contributions

  • Please refer to Google Scholar for a comprehensive list of academic journal publications: https://scholar.google.co.nz/citations?user=eVL8QtsAAAAJ&hl=en

     

    Selected peer-reviewed journal papers:

     ·         Tremain P, Chan C-HA, Rowbotham D, Lim G, O’Grady G, Cheng LK, McKeage J, Angeli-Gordon TR. Endoscopic mapping of bioelectric slow waves in the gastric antrum. Device. Accepted: awaiting e-pub ahead of print, Jan 2024.

     ·         Dowrick JM, Jungbauer Nikolas L, Offutt SJ, Tremain P, Erickson JC, Angeli-Gordon TR. Translation of an existing implantable cardiac monitoring device for measurement of gastric electrical slow-wave activity. Neurogastroenterol. Motil. 36:e14723, 2024.

     ·         Simmonds S, Cheng LK, Ruha WW, Taberner A, Du P, Angeli-Gordon TR. Measurement and analysis of in vivo gastroduodenal slow wave patterns using anatomically-specific cradles and electrodes. IEEE Trans. Biomed. Eng. In Press: E-pub ahead of print, 2023.

     ·         Nagahawatte ND, Avci R, Angeli-Gordon TR, Paskaranandavadivel N, Cheng LK. High-energy pacing in the jejunum elicits pulsatile segmental contractions. IEEE Trans. Biomed. Eng. In press: E-pub ahead of print, 2023.

    *Selected as a ‘feature article’ by the Editorial Board.

     ·         Matthee A, Aghababaie Z, Simmonds S, Dowrick J, Nisbet LA, Sands GB, Angeli-Gordon TR. Power-controlled, irrigated radio-frequency ablation of gastric tissue: a biophysical analysis of lesion formation. Dig. Dis. Sci. 68(10):3953-3962, 2023.

     ·         Aghababaie Z, Wang TH-H, Nisbet LA, Matthee A, Dowrick J, Sands GB, Paskaranandavadivel N, Cheng LK, O’Grady G, Angeli-Gordon TR. Anaesthesia by intravenous propofol reduces the incidence of intra-operative gastric electrical slow-wave dysrhythmias compared to isoflurane. Sci. Rep. 13: 11824, 2023.

     ·         Aghababaie Z, O’Grady G, Nisbet LA, Modesto AE, Chan C-HA, Matthee A, Amirapu S, Beyder A, Farrugia G, Asirvatham SJ, Sands GB, Paskaranandavadivel N, Cheng LK, Angeli-Gordon TR. Localized bioelectrical conduction block from radiofrequency gastric ablation persists after healing: safety and feasibility in a recovery model. Am. J. Physiol. Gastrointest. Liver Physiol. 323(6):G640-G652, 2022.

     ·         Aghababaie Z, Cheng LK, Paskaranandavadivel N, Avci R, Chan C-HA, Matthee A, Amirapu S, Asirvatham SJ, Farrugia G, Beyder A, O’Grady G, Angeli-Gordon TR. Targeted ablation of gastric pacemaker sites to modulate patterns of bioelectrical slow wave activation and propagation in an anesthetized pig model. Am. J. Physiol. Gastrointest. Liver Physiol. 322(4):G431-445, 2022.
    *Selected as journal cover feature.

    *Awarded ‘Best Published Paper in 2022’, Auckland Bioengineering Institute.

     

    ·         Chan C-HA, Aghababaie Z, Paskaranandavadivel N, Avci R, Cheng LK, Angeli-Gordon TR. Localized gastric distension disrupts slow wave entrainment leading to temporary ectopic propagation: a high-resolution electrical mapping study. Am. J. Physiol. Gastrointest. Liver Physiol. 321(6):G656-G667, 2021.

    ·         Aghababaie Z, Paskaranandavadivel N, Amirapu S, Chan C-HA, Du P, Asirvatham SJ, Farrugia G, Beyder A, O’Grady G, Cheng LK, Angeli-Gordon TR. Gastric ablation as a novel technique for modulating electrical conduction in the in vivo stomach. Am. J. Physiol. Gastrointest. Liver Physiol. 320(4):G573-G585, 2021.

    ·         Kamat AA, Paskaranandavadivel N, Alighaleh S, Cheng LK, Angeli TR. Effects of electrode diameter and contact material on signal morphology of gastric bioelectrical slow wave recordings. Ann. Biomed. Eng. 48(4):1407-1418, 2020.

    ·         Wang TH-H, Angeli TR, Beban G, Du P, Bianco F, Gibbons SJ, Kramer N, Windsor JA, Cheng LK, O’Grady G. Slow wave coupling across a gastroduodenal anastomosis as a mechanism for postsurgical gastric dysfunction: evidence for a “gastrointestinal aberrant pathway”. Am. J. Physiol. Gastroinest. Liver Physiol. 317(2):G141-G146, 2019.

    ·         Abraham A, Cheng LK, Angeli TR, Alighaleh S, Paskaranandavadivel N. Dynamic slow wave interactions in the rabbit small intestine defined using high resolution mapping. Neurogastroenterol. Motil. 31(9):e13670, 2019.

    *Selected as journal cover feature.

    *Selected as a Finalist for ‘Best Published Paper in 2019’, Auckland Bioengineering Institute.

    ·         Angeli TR, O’Grady G, Vather R, Bissett IP, Cheng LK. Intra-operative high-resolution mapping of slow-wave propagation in the human jejunum: feasibility and initial results. Neurogastroenterol. Motil. 30(7):e13310, 2018.

    *Selected as journal cover feature.

     

    ·         Mayne TP, Paskaranandavadivel N, Erickson JC, O’Grady G, Cheng LK, Angeli TR. Improved visualization of gastrointestinal slow wave propagation using a novel wavefront-orientation interpolation technique. IEEE Trans. Biomed. Eng. 65(2):319-326, 2018.

    ·         Erickson JC, Hayes J, Bustamante M, Joshi R, Rwagaju A, Paskaranandavadivel N, Angeli TR. Intsy: a low-cost, open-source, wireless multi-channel bioamplifier system. Phys. Meas. 39(3):035008, 2018.

    ·         Angeli TR, Du P, Paskaranandavadivel N, Sathar S, Hall A, Asirvatham SJ, Farrugia G, Windsor JA, Cheng LK, O’Grady G. High-resolution electrical mapping of porcine gastric slow-wave propagation from the mucosal surface. Neurogastroenterol. Motil. 29(5):e13010, 2017.

    ·         Angeli TR, Du P, Midgley D, Paskaranandavadivel N, Sathar S, Lahr C, Abell TL, Cheng LK, O’Grady G. Acute slow wave responses to high-frequency gastric electrical stimulation in patients with gastroparesis defined by high-resolution mapping. Neuromodulation. 19(8):864-871, 2016.

    ·         Erickson JC, Putney J, Hilbert D, Paskaranandavadivel N, Cheng LK, O’Grady G, Angeli TR. Iterative covariance-based removal of time-synchronous artifacts: application to gastrointestinal electrical recordings. IEEE Trans. Biomed. Eng. 63(11):2262-2272, 2016.

    ·         Angeli TR, Cheng LK, Du P, Wang T, Bernard CE, Vannucchi M-G, Faussone-Pellegrini MS, Lahr C, Vather R, Windsor JA, Farrugia G, Abell TL, O’Grady G. Loss of interstitial cells of Cajal and patterns of gastric dysrhythmia in patients with chronic unexplained nausea and vomiting. Gastroenterology. 149(1):56-66.e5, 2015.

    *Highlighted by “News and Views” editorial in Nature Reviews, Gastroenterology and Hepatology, 2015.

    *Highlighted by a feature article in ‘New Zealand Health Research Council News’, September 2015.

     

    ·         Angeli TR, Du P, Paskaranandavadivel N, Janssen PWM, Beyder A, Lentle RG, Bissett IP, Cheng LK, O’Grady G. The bioelectrical basis and validity of gastrointestinal extracellular slow wave recordings. J. Physiol. 591(18):4567-4579, 2013.

    *Highlighted by feature editorial.

    *Selected as “Editor’s Choice.”

     

    ·         Angeli TR, O’Grady G, Du P, Paskaranandavadivel N, Pullan AJ, Bissett IP, Cheng LK. Circumferential and functional re-entry of in vivo slow-wave activity in the porcine small intestine. Neurogastroenterol. Motil. 25(5):e304-314, 2013.

    *Highlighted by feature editorial.

     

    ·         Angeli TR, O’Grady G, Paskaranandavadivel N, Erickson JC, Du P, Pullan AJ, Bissett IP, Cheng LK. Experimental and automated analysis techniques for high-resolution electrical mapping of small intestine slow wave activity. J. Neurogastroenterol. Motil. 19(2):179-191, 2013.

    *Selected as journal cover feature.

     

    ·         O’Grady G, Angeli TR, Du P, Lahr C, Lammers WJEP, Windsor JA, Farrugia G, Abell T, Cheng LK, Pullan AJ. Abnormal initiation and conduction of slow-wave activity in gastroparesis, defined by high-resolution electrical mapping. Gastroenterology. 143:589-598, 2012.

    *Highlighted as “lead news story” in Nature Reviews, Gastroenterology and Hepatology, July 2012.

    *Awarded “Best Published Paper 2012” by the New Zealand Society of Gastroenterology.

    *Awarded “Top Publication in 2012 from an Emerging Researcher” by The University of Auckland Faculty of Medical and Health Sciences.

     

    Other selected outputs:

     ·        Angeli-Gordon TR. Secrets of the electric stomach. Raising the Bar Public Lecture Series, University of Auckland, at Good George North Wharf Pub, Auckland. 29 August, 2023.

     ·        Angeli-Gordon TR. Radio interview on ‘Secrets of the electric stomach.’ Radio New Zealand, Afternoons with Jesse Mulligan. 25 August, 2023.

     ·        Angeli-Gordon TR. Radio interview on advances in stomach research, particularly highlighting our work on gastric ablation. Today FM. 20 April, 2022.

     ·        Angeli-Gordon TR. ‘Māramatanga’ column on the importance of being a Pākehā ally for te ao Māori in academia. UniNews. September, 2021.
    https://www.auckland.ac.nz/en/news/2021/08/31/tim-angeli-gordon-privilege-of-becoming-a-cultural-ally.html

      

    Postgraduate Student Supervision:

     ·   Mr Peter Tremain

    PhD in Bioengineering, University of Auckland, NZ. 2022 – present.

    ‘Endoscopic mapping of human gastric electrical activity.’

    *Awarded ‘Prime Minister’s Scholarship for Latin America’ from Education New Zealand Manapou ki te Ao, NZ, 2023.

    *Awarded ‘RHT Bates Postgraduate Scholarship’ from the Royal Society Te Apārangi, NZ, 2023.

    *Awarded ‘Student Travel Award’, Japan Digestive Disease Week (JDDW) conference, Kobe, Japan, Nov 2023.

    *Selected to Vanguard Program for entrepreneurial leaders at the University of Auckland, delegation to Silicon Valley, CA, USA, Aug/Sept 2023.

    *Awarded ‘Basic Science Travel Award’, Digestive Disease Week (DDW) conference, Chicago, USA, May 2023.

    *Awarded University of Auckland Doctoral Scholarship, 2022-2025.

     

    ·       Mr Sam Simmonds

    PhD in Bioengineering, University of Auckland, NZ, 2021 – present.

    “Inter-organ communication in the gut: elucidating the bioelectrical basis of the gastro-intestinal junction”

    *Awarded the ‘Alvarez Award for best abstract’ at the International Gastrointestinal Electrophysiology Society conference, Chicago, USA, 2023.

     

    ·       Mr Ashton Matthee

    PhD in Bioengineering, University of Auckland, NZ, 2021 – present.

    “Development of endoscopic mucosal ablation to modulate gastric electrical activation patterns”

    *Awarded ‘Winner’ of the Pecha Kucha presentation category (2 min recorded presentation), School of Graduate Studies Research Showcase, University of Auckland, NZ, 2023.

    *Awarded ‘Poster of Excellence’ at the New Zealand Society of Gastroenterology, Auckland, NZ, 2022.

     

    ·       Dr Tim H-H. Wang

    PhD in Surgery, University of Auckland, NZ, 2016 – present (part-time).

    “Advances in the investigation and management of post-operative gastric arrhythmias”

    *Awarded ‘Best Upper GI Research Presentation’ at the Royal Australasian College of Surgeons (RACS) Annual Scientific Meeting, Bangkok, Thailand, 2019.

     

    ·       Dr Chih-Hsiang Alexander Chan

    PhD in Bioengineering, University of Auckland, NZ, 2018-2023.

    “A new visualisation pipeline for high-resolution gastrointestinal electrical mapping data: New algorithms, visual encodings, and software”

    *Awarded Young Investigator Award at the International Gastrointestinal Electrophysiology Society Annual Scientific Meeting, San Diego, USA, 2019.

     

    ·       Dr Zahra Aghababaie

    PhD in Bioengineering, University of Auckland, NZ, 2018-2023.

    “Targeted ablation therapy for treatment of gastrointestinal dysrhythmias”

    *Dean’s List 2022 for Excellence

    *Best Publication in 2022, Auckland Bioengineering Institute.

    *Young Investigator Award (Runner-up), NZ Society of Gastroenterology, 2021.

    *Runner-up for Best Presentation, Auckland Bioengineering Institute Research Forum, 2021.

     

    ·       Mr Peter Tremain

    Master’s in Bioengineering, University of Auckland, NZ, 2020-2022.

    “Endoscopic mapping of human gastric slow wave activation”

    * Received 1st Class Honours.

    * Awarded Fowlds Memorial Prize (ABI) for best Master’s thesis in 2022.

     

    ·       Ms Kiara Miller

    Master’s in Bioengineering, University of Auckland, NZ, 2019-2020.

    “Slow wave mapping of the rabbit small intestine, caecum, and colon”

    * Received 1st Class Honours.

     

    ·       Ms Nova Belle Pavel Nagalakshmi

    Master’s in Engineering Studies, University of Auckland, NZ, 2019-2020.

    “Defining the consistency of gastric slow wave signal morphology acquired by high-resolution electrical mapping”

     

    ·       Mr Abhishek Kamat

    Master’s in Bioengineering, University of Auckland, NZ, 2017-2018.

    “Determining the effects of electrode diameter and protrusion on signal morphology of gastrointestinal bioelectrical recordings”

    * Received 1st Class Honours.

     

    ·       Mr Ashley Abraham

    Master’s in Bioengineering, University of Auckland, NZ, 2017-2018.

    “Quantification of high-resolution rabbit intestine slow wave dynamics”

    * Received 1st Class Honours.

    * Awarded Fowlds Memorial Prize (ABI) for best Master’s thesis in 2018.

    * Selected as Finalist for ‘Best Published Paper in 2019,’ Auckland Bioengineering Institute.